منابع مشابه
Retinoblastoma Progression
The Vision Center, Division of Pediatric Ophthalmology, Department of Surgery, and The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, United States USC Eye Institute, Department of Ophthalmology, and Norris Comprehensive Cancer Center, Keck School ofMedicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033,...
متن کاملRetinoblastoma: Animal Models of Tumor Progression
To generate animal models of retinoblastoma that closely resemble metastatic and nonmetastatic human disease for the purposes of examining tumor biology and of developing alternate treatments, human retinoblastoma cell lines were injected into the vitreal cavities of immunodeficient mice. Two reproducible animal models with contrasting biologic behavior analogous to human retinoblastoma have be...
متن کاملmiRNA signature identification of retinoblastoma and the correlations between differentially expressed miRNAs during retinoblastoma progression.
PURPOSE Retinoblastoma (RB) is a common pediatric cancer. The study aimed to uncover the mechanisms of RB progression and identify novel therapeutic biomarkers. METHODS The miRNA expression profile GSE7072, which includes three RB samples and three healthy retina samples, was used. After data normalization using the preprocessCore package, differentially expressed miRNAs (DE-miRs) were select...
متن کاملRetinoblastoma Loss Modulates DNA Damage Response Favoring Tumor Progression
Senescence is one of the main barriers against tumor progression. Oncogenic signals in primary cells result in oncogene-induced senescence (OIS), crucial for protection against cancer development. It has been described in premalignant lesions that OIS requires DNA damage response (DDR) activation, safeguard of the integrity of the genome. Here we demonstrate how the cellular mechanisms involved...
متن کاملBasic fibroblast growth factor impact on retinoblastoma progression and survival.
PURPOSE Chemotherapy resistance is a problem in the treatment of advanced retinoblastoma (RB). Since basic fibroblast growth factor (bFGF) is a survival factor for neural precursor cells, bFGF was evaluated as a growth and chemoresistance factor in RB. METHODS bFGF expression was analyzed in the LH-betaTag transgenic mouse model of RB and human RB cell lines by immunofluorescence, RT-PCR, and...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2015
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2015.07.023